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However, there is a need for rigorous patient selection and close follow-up, as AHSCT involves significant risk, including treatment-related mortality (estimated at about 0.2% in the most recent data) and the development of secondary autoimmune disease

Xu, K., Xu, Y.-H., Chen, J.-F

Cytoprotective Pathways: FAK-Paxillin Signaling and Growth Hormone Receptor Interaction Focal Adhesion Kinase: The Structural Survival Signal Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates signals from integrins the transmembrane proteins that anchor cells to extracellular matrix with intracellular survival and migration pathways

This work has clinical relevance as MaT and MiT variants of NC-HCC may respond better to tyrosine kinase inhibitors and immunotherapy respectively

They can use the acronym COLDERAS (Characteristics, Onset, Location, Duration, Exacerbation, Radiation, Relief, Associated Symptoms) as another tool to assess the patients pain experience (2)(85)